Hilton is teaming up with Eden Group, a Myanmar conglomerate with businesses from hotels to energy.
Hilton says it will rebrand Eden hotels in the capital Nay Pyi Taw and Ngapali beach in western Rakhine state. It will open hotels in Inle lake in Shan State, Bagan in central Myanmar and the central city of Mandalay.
It plans to open a hotel in Yangon under a separate deal announced last year.
The number of tourists to Myanmar has surged in the past two years though it still lacks sufficient hotel rooms and infrastructure to challenge neighbouring Thailand as a major destination.