The Monetary Authority of Singapore (MAS) said on Wednesday that given the "risks associated with large value cash transactions and high-value notes", it will stop producing the S$10,000, though those already in circulation will remain legal tender indefinitely.
High value notes are popular with organised criminals as they are a lighter, more efficient way of carrying large amounts of cash.
In 2010, Britain's Serious Organised Crime Agency estimated that 90% of 500 euro banknotes sold from exchange bureaus in the country were in the hands of organised criminals.
Singapore is tightening its scrutiny of cash-intensive sectors such as casinos and money remittance agents to try and ensure they are not used to launder the proceeds of crime.
The wealthy island-nation opened two multi-billion dollar gaming resorts in 2010 that attract thousands of high-rolling gamblers from overseas, an industry that a government report warned last year could be vulnerable to money laundering.
Ong Chong Tee, a deputy managing director of MAS, said he felt ending production of the $10,000 note was unlikely to cause much inconvenience.
"The development of more advanced and secured electronic payment systems has reduced the need for large value cash-based transactions," he said in a speech at a financial crime seminar.
Singapore will however continue to have some high-value paper, with the central bank still issuing S$1,000 notes. By comparison, the highest-value denomination in the United States is $100.