An early rally in response to the US gains fizzled towards the end of the day as profit-takers moved in.
Tokyo ended flat, edging down 9.04 points to finish at 15,370.26 as the yen strengthened against the dollar, while Sydney was marginally higher, adding 3.54 points to 5,522.4 and Seoul gained 0.37%, or 7.42 points, to 2,020.90.
Shanghai lost 0.57%, or 11.69 points, to 2,055.59 while Hong Kong was a touch lower, dipping 2.41 points to 23,520.87.
Taipei fell 0.81%, or 76.49 points, to 9,408.24 and Manila closed 0.49% higher, adding 33.32 points to 6,867.36.
Singapore was flat, edging up 2.46 points to 3,306.89 Kuala Lumpur slipped 3.57 points, or 0.19%, to end at 1,883.14 and Jakarta fell 0.84, or 42.73 points, to 5,071.20.
The mood remained largely buoyant after China said on Wednesday that the world's number two economy and key driver of global growth expanded more than expected in the second quarter of the year.
US shares resumed their uptrend on Wednesday as traders welcomed a report from the Fed that said all 12 economic regions of the country continued to expand in the six weeks to July 7.
Pointing to generally higher consumer spending, with strong auto sales outperforming other retail segments, the bank's Beige Book report is the latest to indicate the world's top economy is getting back on track.
It also comes weeks after the Labour Department said far more jobs were created in June than forecast while unemployment slipped.
On Wall Street the Dow jumped 0.45% to a new record, while the S&P 500 gained 0.42% and the Nasdaq added 0.22%.
The US market was also cheering better-than-expected earnings from chip giant Intel and a "landmark" IBM partnership with Apple.
On currency markets the dollar dipped to 101.49 yen in Asian trade from 101.69 yen in New York Wednesday.
The greenback had enjoyed a rally on Wednesday after Fed chief Janet Yellen told lawmakers on Capitol Hill that interest rates could rise "sooner and be more rapid than currently envisioned" if the jobs market strengthens further.
The euro bought $1.3530 and 137.33 yen in Tokyo, against $1.3524 and 137.55 yen in US trade.